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Updated: Sep 02, 2025

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ASCP-MLT Practice Q&A's

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ASCP MEDICAL LABORATORY TECHNICIAN - MLT(ASCP) Sample Questions:

1. Interferon gamma serves various purposes in immunologic response, including the promotion of natural killer cell activity as well as decreased viral replication by using enzymes to decrease protein replication, both viral or host, inside of the cell.
The lymphokine most important for increased natural killer cell activity and decreased viral replication in cells is:

A) Interleukin 5
B) Interferon gamma
C) Interleukin 4
D) Interleukin 3


2. Platelets do not circulate in inactivated, spiny forms. The spiny, sticky form of the platelet is initiated once the platelets become activated in response to blood vessel damage.
Which of the following is not true in terms of platelet characteristics?

A) Possess an inherent sticky property that aids in adhesion and aggregation.
B) Have a lifespan of roughly 9-12 days.
C) Produced in the bone marrow by megakaryocytes.
D) Are normally found circulating in their inactive, spiny form.


3. The role of the point-of-care testing (POCT) compared with in-laboratory testing is the

A) Process of performin laboratory testing at the bedside of the patient and a means of decentralizing some of the laboratory testing
B) Continuation of the process of evaluating and monitoring all aspects of the laboratory to ensure accuracy of test results
C) Specific microscopic tests (wet mounts) performed by a physician for his or her own patients
D) Means by which quality control between laboratories is maintained


4. Caffeine benzoate solution is used to split the unconjugated bilirubin protein complex releasing the bilirubin so that it can react with diazotised sulphanilic acid. The tartrate buffer creates an alkaline solution and converts the red acid bilirubin to a green coloured compound which can be measured spectrophotometrically.
Which substance is used in the Jendrassik-Grof method to accelerate the reaction of unconjugated bilirubin with the diazo reagent?

A) N-butanol
B) caffeine
C) NADH
D) acetic acid


5. Howell-Jolly bodies are composed of DNA and appear as small round ball-like inclusions inside the red cells.
Usually only one Howell-Jolly body will be present in each red cell.
Single erythrocyte inclusions which are large, round, smooth and purplish-blue staining are most likely:

A) Cabot rings
B) Howell-Jolly bodies
C) Basophilic stippling
D) Heinz bodies


Solutions:

Question # 1
Answer: B
Question # 2
Answer: A
Question # 3
Answer: A
Question # 4
Answer: A
Question # 5
Answer: B

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