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Updated: Aug 13, 2026

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ACRP ACRP-CP Exam Overview:

Certification Vendor:Association of Clinical Research Professionals (ACRP)
Exam Name:ACRP Certified Professional Exam
Exam Number:ACRP-CP
Related Certifications:ACRP Certified Clinical Research Associate (CCRA)
ACRP Certified Clinical Research Coordinator (CCRC)
ACRP Certified Principal Investigator (CPI)
Certificate Validity Period:3 years
Exam Format:Multiple-choice questions, Recall questions, Scenario-based questions
Available Languages:English
Exam Duration:180 minutes
Passing Score:Scaled score of 600 or higher
Real Exam Qty:125 (100 scored, 25 pre-test)
Exam Price:$435 – $600
Recommended Training:ACRP Official Training Resources
Exam Registration:ACRP Official Registration
Sample Questions:ACRP ACRP-CP Sample Questions
Exam Way:Online remote proctored or in-person at PSI test centers
Pre Condition:3,000 hours verifiable clinical research work experience; or 1,500 hours plus clinical research degree
Official Syllabus URL:https://acrpnet.org/certification/acrp-cp-certification

ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Clinical Study Operations15%- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
- Site management
  • 1. Study documentation and record keeping
  • 2. Site personnel training and delegation
Data Management and Informatics17%- Data reporting
  • 1. Data integrity and security
  • 2. Database lock and data transfer
- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
- Data collection
  • 1. Electronic data capture systems
  • 2. Case report form design and completion
Study Design and Conduct17%- Study planning
  • 1. Protocol development and amendments
  • 2. Study population and eligibility criteria
  • 3. Sample size and statistical considerations
- Study implementation
  • 1. Investigational product management
  • 2. Study monitoring and oversight
  • 3. Site selection and activation
Professionalism and Ethical Practice15%- Continuous improvement
  • 1. Quality assurance and process improvement
  • 2. Professional development and education
- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
Ethical and Participant Safety Considerations19%- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
- Clinical care and management of research participants
  • 1. Continuity of medical care
  • 2. Standard of care vs protocol requirements
  • 3. Informed consent development and review
Regulatory and Compliance Requirements17%- Compliance procedures
  • 1. Regulatory submissions and approvals
  • 2. Audits and inspections
- International standards
  • 1. Declaration of Helsinki
- ICH Guidelines
  • 1. E8 General Considerations for Clinical Trials
  • 2. E9 Statistical Principles
  • 3. E2A Expedited Reporting
  • 4. E11 Pediatric Trials
  • 5. E6(R2)/E6(R3) Good Clinical Practice

ACRP Certified Professional Sample Questions:

1. The IRB/IEC has decided to not approve a clinical trial. Who must they notify in writing?

A) Regulatory Agency
B) PI
C) CRC
D) Sponsor


2. The objective of a randomized clinical trial is to look at whether an IP is effective in preventing recurrence of a disease. What would be a possible primary endpoint of the trial?

A) Use of concomitant medications to treat the symptoms
B) Impact of an approved vaccine against the disease
C) Occurrence of known side effects of the IP
D) Time to occurrence of symptoms of the disease


3. A site is starting up a Phase III trial. They have received IRB/IEC approval and have scheduled the SIV. The site cannot begin enrolling subjects until:

A) The DSMB meets and the first DSMB meeting report has been issued.
B) A signed clinical trial agreement between the site and sponsor is in place.
C) The site receives approval from the medical monitor to begin enrolling.
D) The CRA has performed source document review and verification at the site.


4. Who should vote during the IRB/IEC review and discussion process?

A) All IRB/IEC members and non-member experts
B) All members who were involved in the review and discussion
C) All IRB/IEC members
D) All members who were involved in the review and discussion and non-member experts


5. Access to study documentation for auditors and inspectors during an audit or inspection at a clinical trial site is the responsibility of the:

A) PI
B) CRC
C) CRA
D) Sponsor


Solutions:

Question # 1
Answer: B
Question # 2
Answer: D
Question # 3
Answer: B
Question # 4
Answer: B
Question # 5
Answer: A

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Frequently Asked Questions

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Online Test Engine can supports Windows / Mac / Android / iOS, etc., because it is the software based on WEB browser. You can use it on any electronic device and practice with self-paced.
Online Test Engine supports offline practice, while the precondition is that you should run it with the internet at the first time.
Self Test Engine is suitable for windows operating system, running on the Java environment, and can install on multiple computers.
PDF Version: can be read under the Adobe reader, or many other free readers, including OpenOffice, Foxit Reader and Google Docs.

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